Drug firms donate compounds for anti-HIV gel

Anti-hiv Drug Targets

ANTI-HIV DRUG TARGETS HIV is a retrovirus, with a simple structure described in Box 1, and illustrated in Figure 1. It contains genes coding for a number of unique viral enzymes, required at different stages of the virus’s life cycle (see Box 2 and Figure 2). One of these is reverse transcriptase, required to make copies of the viral genes once it has infected human cells. Another is HIV protea...

Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata.

Three new compounds (1 - 3), including a sesterterpenoid, aspterpenacid C (1), with an unusual 5/3/7/6/5 pentacyclic skeleton, together with seven known ones (4 - 10), were isolated from the ethanol extract of the traditional Chinese medicinal plant Swertia bimaculata. Their structures were elucidated on the basis of the methods of spectroscopic NMR, MS, and computational chemistry. The structu...

Formulation Development and Evaluation of in Situ Gel for Vaginal Drug Delivery of Anti Fungal Drug

The aim of the present study was to formulate and evaluate nystatin containing thermosensitive mucoadhesive gel for vaginal drug delivery to achieve prolonging the residence time, sustained drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance in the treatment for vaginal candidiasis. Here nystatin (1%) as a model drug. A 3 full factorial design was employed...

Toward the Development of a Single-Round Infection Assay Based on EGFP Reporting for Anti-HIV-1 Drug Discovery

Background: The rapid increase of HIV-1 strains resistant to current antiretroviral drugs is a challenge for successful AIDS therapy. This necessitates the development of novel drugs, and to this end, availability of screening systems for in vitro drug discovery is a priority. Herein, we report the modification of a previously developed system for increased sensitivity, ease of use, and cost-ef...

Anti-HIV activity of compounds isolated from Elaeodendron transvaalense